VISGEN - Transcribing the processes of life: Visual Genetics

Transcribing the processes of life: Visual Genetics

The Visual Genetics (VISGEN) consortium brings together eight academic and five commercial scientifically leading teams to address the unique challenge of visualizing nuclear processes in intact brain in real-time. By exchanging knowledge between academic and commercial sectors in Europe, as well as undertaking training secondments at leading Universities in China the team will grow its European and global competitiveness in a world-leading forefront of neuroscience and genetic technology. Visualisation of transcription in living systems has not been witnessed directly, this multidisciplinary and international project will herald a new era where this idea becomes a regular research tool and translates to a clinical and diagnostic technology in the future. The team will use a unique biotagging platform to develop the technology that is required to interrogate transcription. The intersectoral effort requires the amalgamation of knowledge from neuroscientists, synthetic chemists, engineers, physicists, analytical chemists, nanobiologists, behavioural scientists, laser technology and image processing experts. The consortium combines expertise from thirteen organisations from seven countries to build the multidisciplinary team and share the knowledge that addresses and will overcome the task of realising real-time and spatially resolved genetic studies. Once developed, the technology can be utilized for other medical-based research and development projects aimed at early stage disease diagnosis, cancer detection, and toxicity studies. Real-time visual genetics will transform our understanding of the state-of-the-art and herald transformative changes in the field of neuroscience, and in general life science.

NEURAM - Visual genetics: establishment of a new discipline to visualize neuronal nuclear functions in real-time in intact nervous system by 4D Raman spectroscopy

Visual genetics: establishment of a new discipline to visualize neuronal nuclear functions in real-time in intact nervous system by 4D Raman spectroscopy

Working as a multi-disciplinary collaboration, this H2020 project aims to combine the knowledge of leading researchers and pioneering industry specialists to hone the technology and expertise needed to develop ground-breaking ways of visualising living tissue. The genetic content of a cell determines its function. Genes are constantly switched on and off from the birth of the cell up until it dies. This highly dynamic process is regulated both by internal (genetic) and external (environmental) factors. In this H2020 funded project we develop a new technology to visualise the active genes in real time.

CLILMED - CLIL in Medical Education: Reaching for Tools toTeach Effectively in English in a Multicultural and Multilingual Learning Space

CLIL in Medical Education: Reaching for Tools toTeach Effectively in English in a Multicultural and Multilingual Learning Space

The main goal of the CLIL in Medical Education project: Reaching for Tools to Teach Effectively in English in a Multicultural and Multilingual Learning Space (CLILMED) is to improve the language qualifications of the teaching staff (English) and cooperation with leading medical schools for innovation and exchange of good practices. Its implementation will start on October 31, 2019.

CLILMED's main assumption is to equip academic teachers with high language competences in the field of medical sciences and health care, which will allow them to work effectively in a multicultural environment, including teaching students from abroad and facilitating stays in foreign research centers. As part of the project, selected academic teachers will be educated based on the CLIL (Content and Language Integrated Learning) method, recommended by the European Commission for the promotion of language learning and linguistic diversity. Important features of this method are: systematic group work, selection of exercises that take into account different types of student intelligence, learning through different sensory channels, the use of sources and materials suitable for conducting integrated teaching, vocabulary useful for the CLIL lesson.

Palliative Sedation - The use of proportional palliative sedation for the relief of refractory symptoms: an international multicenter study

The use of proportional palliative sedation for the relief of refractory symptoms: an international multicenter study — ‘PalliativeSedation’

Due to the rise in cancer and multiple chronic disease, the number of patients with refractory symptoms, ie severe symptoms where conventional treatment options fail, is likely to increase. In such cases palliative sedation (PS) can be indicated which involves the intentional lowering of consciousness at the end of life. However PS is too often restricted to continuous deep sedation and confused with hastening of death. This proposal offers a modified concept, namely proportional PS, with titration of sedatives up to the point of symptom control to improve patient comfort. Firstly, the project will offer a review about state-of-the-art refractory symptom management and a country survey. Secondly, an observational multicenter study will be performed in five countries to study the effect of proportional PS at patient comfort and symptom relief. Thirdly, a multiple case study of 50 cases will investigate caregivers and family experiences. Fourthly, moral case deliberation will be studied as a tool to improve multidisciplinary decision making for the treatment of refractory symptoms/PS in 16 clinical centers in 8 countries, including the effect on caregiver emotional distress. Fifthly, a Cost Consequence Analysis will be provided to feed a policy workshop and recommendations for the further development of palliative sedation in Europe. Sixthly, a revision of the 2009 EAPC framework for PS will be undertaken, using a Delphi procedure. Finally, a free online education programme will be delivered together with an abook and a closing congress and webinar to support dissemination. The project consortium consists of experts in the field of palliative care and PS from 8 North-Western, Southern, and Central-Eastern European countries. Renowned advisory board members are involved among which the European Cancer Patient Coalition to foster the patient perspective. A dedicated European taksforce for PS is foreseen as a follow up after the project's finalization.